Utilizing Direct Memory Access connections avaiable on modern computers it is possible to access main memory without any operating system supervision. This means access to Ring 0, allowing for anything from access to cryptographic information to running malware without credentials, if unmitigated.
Connections which allow DMA include:
FireWire
CardBus
ExpressCard
Thunderbolt
USB 4.0
PCI, PCI-X and PCI Express
Efficacy on Windows 10
Windows > 8.1 introduced protections against Thunderbolt and CFexpress ports. Win 10 v1903 introduced additional protections for other internal PCIe ports (including M.2 slots).